| This meta-analysis evaluated the clinical efficacy of preemptive use of parecoxib in alleviating pain after artificial joint replacement. |
| We included nine randomized controlled trials comparing preemptive use of parecoxib with placebo treatment. |
| Preemptive analgesia with parecoxib can relieve pain after artificial joint replacement, while sparing opioid analgesic consumption without increasing the incidence of adverse events. |
| We recommend preemptive analgesia with parecoxib in patients with artificial joint replacement. |
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