Table 2.

Animal studies on the role of NDRG1

Tumor type	Results	References
Colorectal cancer	ΔNDRG1: ↑tumor growth and liver metastasis	[31]
Colorectal cancer	ΔNDRG1: ↑invasion and metastasis	[32]
Colorectal cancer	ΔNDRG1: ↑tumor growth and tumor weight	[33]
Colorectal cancer	ΔNDRG1: ↑tumor growth and lung metastasis	[34]
Colorectal cancer	ΔNDRG1: ↑invasion and metastasis	[35]
Colorectal cancer	ΔNDRG1: ↑tumor growth	[36]
Breast cancer (TNBC)	ΔYAP1(interaction with NDRG1): ↓tumor growth ↑↑ NDRG1: ↑ cell growth	[4]
Breast cancer	NDRG1 was co-expressed with and β-casein or MFP Up-regulation of NDRG1 resulted in the expansion of the differentiated area	[2]
Gastric cancer	ΔNDRG1: ↑tumor weight and tumor volume	[28]
Nasopharyngeal cancer	ΔNDRG1: ↑cell proliferation	[54]
Non-small-cell lung cancer	ΔNDRG1: ↓tumor growth, tumor volume and angiogenesis	[48]
Osteosarcoma	Δ LncRNA NDRG1: ↓Tumor mass and volume and lung metastasis	[38]
Osteosarcoma	ΔHER4 (interaction counterpart of NDRG1): ↓ tumor growth ↑↑NDRG1: ↑ tumor growth	[40]
Prostate cancer	↓ NDRG1: ↑ tumor growth Δ N-cadherin (interaction counterpart of NDRG1): ↓invasion and metastasis	[14]
Prostate cancer	↑↑ MLL5α (interaction counterpart of NDRG1): ↓tumor growth	[16]
Prostate cancer	Δ E6AP (interaction counterpart of NDRG1): ↓tumor growth	[21]
Clear cell renal cell carcinoma	Δ NDRG1: ↑tumor growth, ↑tumor volume and lung metastasis	[57]