Problem Is the problem a priority?
Judgment	Research evidence	Additional considerations
Probably yes	In epidemiological studies, there is a relationship between the amount of aerobic exercise (at least 150 min/week) and health outcomes20. The identification of a minimum useful threshold of the duration of physical exercise needed for a therapeutic effect in type 2 diabetes is clinically relevant
Desirable Effects How substantial are the desirable anticipated effects?
Judgment	Research evidence	Additional considerations
Small	After updating the previous meta-analysis19 a significant lower fat mass (%) was observed among patients allocated to the intervention group. No differences in HbA1c, BMI
Undesirable Effects How substantial are the undesirable anticipated effects?
Judgment	Research evidence	Additional considerations
Trivial	No relevant risk associated with physical exercise duration was detected in available RCTs, even after updating the previous meta-analysis30
Certainty of evidence What is the overall certainty of the evidence of effects?
Judgment	Research evidence	Additional considerations
Very low	Very low for all critical outcomes
Values Is there important uncertainty about or variability in how much people value the main outcomes?
Judgment	Research evidence	Additional considerations
No important uncertainty or variability	No evidence of variability or uncertainty HbA1c and BMI are already considered among critical outcomes of the treatment of type 2 diabetes by scientific societies
Balance of effects Does the balance between desirable and undesirable effects favor the intervention or the comparison?
Judgment	Research evidence	Additional considerations
Probably favors the intervention	Small but significant effect on HbA1c
Resources required How large are the resource requirements (costs)?
Judgment	Research evidence	Additional considerations
Trivial	No specific evidence is available on this issue
Certainty of evidence of required resources What is the certainty of the evidence of resource requirements (costs)?
Judgment	Research evidence	Additional considerations
Very low	No specific evidence is available on this issue
Cost-effectiveness Does the cost-effectiveness of the intervention favor the intervention or the comparison?
Judgment	Research evidence	Additional considerations
Probably favors the intervention	Small advantage for HbA1c at no estimated additional cost
Equity What would be the impact on health equity?
Judgment	Research evidence	Additional considerations
Probably no impact	No expected differences in costs and accessibility
Acceptability Is the intervention acceptable to key stakeholders?
Judgment	Research evidence	Additional considerations
Probably yes	No specific evidence is available on this issue
Feasibility Is the intervention feasible to implement?
Judgment	Research evidence	Additional considerations
Yes	No additional costs or resources are required