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. 2023 Jun 23;6:664. doi: 10.1038/s42003-023-05043-2

Fig. 4. NUP98 co-localizes with HDAC1 on chromatin and cooperates with HDAC in gene regulation.

Fig. 4

a Occupancy of other epigenetic marks or regulators in NUP98 ChIP-seq peak regions. b Heatmap comparing NUP98 ChIP-seq and HDAC1 ChIP-seq on NUP98 peaks. c, d Browser tracks showing the co-occupancy of NUP98 and HDAC1 on representative target genes. e, f Crosslinking co-immunoprecipitation using NUP98 or RAE1 antibody to detect HDAC1. g qRT-PCR showing the relative expression of RAE1-NUP98 target genes with HDAC inhibition (one-way ANOVA with post-hoc test, N = 3, data are represented as mean ± standard deviation). hVenn diagram showing the overlap of NUP98, RAE1, and HDACi differentially expressed genes. i Heatmap showing the expression of the differentially expressed genes shared among NUP98 knockdown, RAE1 knockdown, and HDAC inhibition.