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. 2023 Jun 23;6:664. doi: 10.1038/s42003-023-05043-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — NUP98 and RAE1 support epidermal progenitor maintenance through binding to chromatin near the transcription start sites of key target genes such as the epigenetic repressor DNMT1. NUP98 and RAE1’s roles in progenitor maintenance depend on two factors: high expression and HDAC activity. The high expression of NUP98 and RAE1 provides the chromatin-binding pool, in addition to their nuclear-pore incorporation; HDAC activity supports NUP98’s binding on chromatin near the TSSs of key target genes, antagonizing the nucleolar localization of NUP98 and RAE1.