Table 2.

Quality evaluation of included studies.

Year	Lead author	A	B	C	D	E	F	G	H	I	J	Total
1993	Laing, R.J.16	+		+					+			3
2000	Qu Qiumin34	+	+						+			3
2001	Cao Yongjun37	+	+	+			+		+			5
2004	Xi Gangming18	+	+	+		+			+			5
2006	Sun Guobing38	+	+				+		+			4
2006	Johannes Woitzik35	+	+	+		+				+	+	6
2007	Hiroaki Sakai40	+	+	+		+			+	+		6
2008	Cam Ertugrul19	+		+			+		+	+		5
2008	Sun Yu12	+	+				+		+			4
2008	Xiang Heng20	+	+				+		+	+		5
2008	Yang Zanzhang21	+	+	+			+		+			5
2009	Yang Debing17	+	+						+			3
2011	Trueman, R, C.22	+	+	+	+	+			+	+		7
2012	Liu Jianren23	+	+	+		+	+		+	+	+	8
2012	Zhao Kai32	+	+				+		+			4
2013	Tang Qiqiang33	+	+	+			+		+	+	+	7
2014	Fan Ruijuan14	+	+			+	+		+			5
2015	Morris, G.P.15	+	+	+		+			+	+	+	7
2015	Smith, H.K.24	+		+		+				+		4
2016	Zheng Jianfeng25	+	+	+			+		+	+		6
2016	Zuo Xialin26	+	+	+		+	+		+	+		7
2016	Cai Qiang13	+		+		+				+	+	5
2017	Melissa, T.L.36	+	+	+		+			+	+	+	7
2019	Wang Dongliang27	+	+	+					+	+		5
2021	Onufriev, M.V.28	+	+	+		+			+	+	+	7
2022	Wang Wenxiu29	+	+	+			+		+	+		6
2022	Yang Zhong30	+	+	+		+			+	+	+	7
2022	Helena, Justic31	+	+	+		+			+	+	+	7

Study quality items are A, Peer-reviewed publication; B, Random grouping; C, Monitoring of physiological parameters (e.g. temperature, blood pressure, gases); D, Blinded conduct of ischemia; E, Blinded assessment of outcomes; F, Use of anesthetic without marked intrinsic neuroprotective properties (e.g., isoflurane, ketamine, halothane); G, Animal with co-morbidities (e.g., diabetic, aged, or hypertensive); H, Sample size calculation; I, Statement of compliance with animal welfare regulations; J, Statement of potential conflict of interests.