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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1986 Sep;49(9):1044–1049. doi: 10.1136/jnnp.49.9.1044

Anticysticercous antibodies in serum and cerebrospinal fluid in patients with cerebral cysticercosis.

T Corona, D Pascoe, D González-Barranco, P Abad, L Landa, B Estañol
PMCID: PMC1029010  PMID: 3760893

Abstract

Fifty-one cases of cerebral cysticercosis proved by surgery or CT scanning were studied prospectively with the ELISA test in order to detect anticysticercous antibodies in blood and CSF. The ELISA test was also performed for detection of antibodies in 20 control patients who had CSF withdrawn during a myelogram and in 119 serum samples of asymptomatic subjects. We found an overall sensitivity of the ELISA test in the blood of 87% with a specificity of 90%. In the CSF we found a sensitivity of 87% with a specificity of 100%. However, when we compared patients with cerebral cysticercosis of a benign type with patients with cerebral cysticercosis of a malignant type we found a serum sensitivity of 75% for the benign group as compared to 93% of the malignant group. The CSF sensitivity was 80% in the benign group and 93% in the malignant group. This difference was statistically significant.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arambulo P. V., 3rd, Walls K. W., Bullock S., Kagan I. G. Serodiagnosis of human cysticercosis by microplate enzyme-linked immunospecific assay (ELISA). Acta Trop. 1978 Mar;35(1):63–67. [PubMed] [Google Scholar]
  2. Bhaskaran C. S. Cerebral cysticercosis as a cause of unnatural deaths: case report. Indian J Med Sci. 1973 Jul;27(7):545–547. [PubMed] [Google Scholar]
  3. Bout D., Dugimont J. C., Farag H., Capron A. Le diagnostic immunoenzymologique des affections parasitaires. II - Immunoenzymologie quantitative sur lame. Lille Med. 1975 Jun-Jul;20(6):561–566. [PubMed] [Google Scholar]
  4. Estañol B., Kleriga E., Loyo M., Mateos H., Lombardo L., Gordon F., Saguchi A. F. Mechanisms of hydrocephalus in cerebral cysticercosis: implications for therapy. Neurosurgery. 1983 Aug;13(2):119–123. doi: 10.1227/00006123-198308000-00002. [DOI] [PubMed] [Google Scholar]
  5. Flisser A., Tarrab R., Willms K., Larralde C. Inmuno electrofo résis y doble immunodifusión en el diagnóstico de la cisticercósis cerebral humana. Arch Invest Med (Mex) 1975;6(1):1–12. [PubMed] [Google Scholar]
  6. Flisser A., Woodhouse E., Larralde C. Human cysticercosis: antigens, antibodies and non-responders. Clin Exp Immunol. 1980 Jan;39(1):27–37. [PMC free article] [PubMed] [Google Scholar]
  7. Humberto Mateos J. Cisticercosis cerebral como problema de salud pública. I. Introducción. Gac Med Mex. 1972 Mar;103(3):225–227. [PubMed] [Google Scholar]
  8. LOMBARDO L., MATEOS J. H. Cerebral cysticercosis in Mexico. Neurology. 1961 Sep;11:824–828. doi: 10.1212/wnl.11.9.824. [DOI] [PubMed] [Google Scholar]
  9. Miller B., Goldberg M. A., Heiner D., Myers A., Goldberg A. A new immunologic test for CNS cysticercosis. Neurology. 1984 May;34(5):695–697. doi: 10.1212/wnl.34.5.695. [DOI] [PubMed] [Google Scholar]
  10. Miller B., Grinnell V., Goldberg M. A., Heiner D. Spontaneous radiographic disappearance of cerebral cysticercosis: three cases. Neurology. 1983 Oct;33(10):1377–1379. doi: 10.1212/wnl.33.10.1377. [DOI] [PubMed] [Google Scholar]
  11. Mohammad I. N., Heiner D. C., Miller B. L., Goldberg M. A., Kagan I. G. Enzyme-linked immunosorbent assay for the diagnosis of cerebral cysticercosis. J Clin Microbiol. 1984 Oct;20(4):775–779. doi: 10.1128/jcm.20.4.775-779.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. NIETO D. Cysticercosis of the nervous system; diagnosis by means of the spinal fluid complement fixation test. Neurology. 1956 Oct;6(10):725–738. doi: 10.1212/wnl.6.10.725. [DOI] [PubMed] [Google Scholar]
  13. Ogilvie B. M., Wilson R. J. Evasion of the immune response by parasites. Br Med Bull. 1976 May;32(2):177–181. doi: 10.1093/oxfordjournals.bmb.a071352. [DOI] [PubMed] [Google Scholar]
  14. Powell S. J., Proctor E. M., Wilmot A. J., MacLeod I. N. Cysticercosis and epilepsy in Africans: a clinical and serological study. Ann Trop Med Parasitol. 1966 Jun;60(2):152–158. doi: 10.1080/00034983.1966.11686399. [DOI] [PubMed] [Google Scholar]
  15. Rydzewski A. K., Chisholm E. S., Kagan I. G. Comparison of serologic tests for human cysticercosis by indirect hemagglutination, indirect immunofluorescent antibody, and agar gel precipitin tests. J Parasitol. 1975 Feb;61(1):154–155. [PubMed] [Google Scholar]
  16. SHOWRAMMA A., REDDY D. B. SILENT CYSTICERCOSIS OF THE BRAIN. AN ANALYSIS OF FIVE CASES WITH SPECIAL REFERENCE TO HISTOPATHOLOGY. Indian J Pathol Bacteriol. 1963 Jul;37:142–147. [PubMed] [Google Scholar]
  17. Sogandares-Bernal F. Immunoglobulins attached to and in the integument of adult Schistosoma mansoni Sambon 1907, from first infection of CF mice. J Parasitol. 1976 Apr;62(2):222–226. [PubMed] [Google Scholar]
  18. Urquhart G. M. Immunological unresponsivensss in parasitic infections. J Parasitol. 1970 Aug;56(4):547–551. [PubMed] [Google Scholar]
  19. Yakoleff-Greenhouse V., Flisser A., Sierra A., Larralde C. Analysis of antigenic variation in cysticerci of Taenia solium. J Parasitol. 1982 Feb;68(1):39–47. [PubMed] [Google Scholar]

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