Table 2.
Possible opportunities to improve disease-specific understanding of rare breast cancer subtypes.
Opportunity Category | Examples |
---|---|
Clinical Trials | Prospective disease-specific trials |
Basket trials enrolling multiple cohorts, each with a distinct rare tumor (e.g.: DART) | |
Retrospective review of outcomes for patients with rare tumors enrolled on completed trials | |
Prospective identification of patients with rare tumors for new trials or on-going platform trials | |
Infrastructure | International collaborations (e.g., International Rare Cancers Initiative) |
Engage cooperative groups (e.g., ETCTN) which enrich for mega-centers where patients with rare breast cancer subtypes often receive care | |
Technology | Real world data to provide retrospective information or to intentionally follow a cohort of patients with a rare subtype of breast cancer prospectively |
Digital pathology and artificial intelligence to prospectively review and register tumors to reduce issues related to overlapping diagnoses and interobserver variability |