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. 2023 Jun 23;9:55. doi: 10.1038/s41523-023-00554-x

Table 2.

Possible opportunities to improve disease-specific understanding of rare breast cancer subtypes.

Opportunity Category Examples
Clinical Trials Prospective disease-specific trials
Basket trials enrolling multiple cohorts, each with a distinct rare tumor (e.g.: DART)
Retrospective review of outcomes for patients with rare tumors enrolled on completed trials
Prospective identification of patients with rare tumors for new trials or on-going platform trials
Infrastructure International collaborations (e.g., International Rare Cancers Initiative)
Engage cooperative groups (e.g., ETCTN) which enrich for mega-centers where patients with rare breast cancer subtypes often receive care
Technology Real world data to provide retrospective information or to intentionally follow a cohort of patients with a rare subtype of breast cancer prospectively
Digital pathology and artificial intelligence to prospectively review and register tumors to reduce issues related to overlapping diagnoses and interobserver variability