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. 2023 Jun 23;13:10241. doi: 10.1038/s41598-023-37116-x

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Visibility of the cleft in apo-transferrin depending on surface orientation. (a) Number of visible clefts per molecule in the LEEH experiment (left) and in the distribution obtained from a set of random projections generated from the PDB model (right). Experiment (on average 30% of the observed molecules feature one visible cleft) and model (one visible cleft observable on 37% of the molecules) are in good agreement. The error bar on the experimental data is based on the different counts of molecules with clearly visible clefts only (18%) and of those including ambiguous cases (43%). For the derivation of the error bars on the model data, see Supplementary Information. (b) Illustration of orientations featuring 0, 1 and 2 visible clefts. Visible clefts are indicated in green, obscured clefts in red.