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. 2023 Jun 23;9:189. doi: 10.1038/s41420-023-01481-3

Fig. 2. Fer-1 attenuates liver injury induced by LPS/D-GalN in mice, accompanied by increased numbers of alternatively activated macrophages.

Fig. 2

a Liver injury was assessed using histopathology and hematoxylin and eosin (H&E) staining, Scale bar = 100 µm. b, c The levels of AST and ALT in serum. d–g Serum content of TNF-α, IL-6, IL-1β, and HMGB1. h Transmission electron microscopy (TEM) shows a representative liver tissue image, Scale bar = 2 μm. i Representative fluorescence imaging of the superoxide anion fluorescence detection probe dihydroethidium (DHE) in liver tissue, Scale bar = 50 µm. j, k Assessment of MDA and GSH contents in liver tissue. l Expression of iNOS and CD206 was detected using immunocytochemistry in the liver tissue, Scale bar = 100 µm. Results were presented as mean ± SD (n = 5). (##p < 0.01, vs. Con. **p < 0.01, vs. D-GalN/LPS. Con Control, NS not significant).