TABLE 3.

The effect of autophagy gene alteration on cell death pathways.

Gene/protein	Gene alteration	Model	Type of cell death	Modulation that occurred	Reference
ATG13	KO	In Vitro MEFs	Ferroptosis	Decreased	Gao et al. (2016)
ATG3	KO	In Vitro MEFs	Ferroptosis	Decreased	Gao et al. (2016)
ULK1/2	KO	In Vitro MEFs	Ferroptosis	Decreased	Gao et al. (2016)
ATG5	KO, KD	In Vitro Cell lines: MEFs, PANC1, PANC2.03, HT-1080, Y79-CR, HepaG2	Ferroptosis	Decreased	Gao et al. (2016), Hou et al. (2016), Bai et al. (2019), Liu et al. (2022)
		In Vivo Model: HepaG2 cells subcutaneously injected in 6- to 8-week-old athymic nude or B6 mice
ATG7	KO, KD	In Vitro Cell lines: MEFs, PANC1, PANC2.03, HT-1080	Ferroptosis	Decreased	Hou et al. (2016)
		In Vitro Cell line: C17.2	LMP-Associated cell death	Decreased	Walls et al. (2010)
		In Vivo ER-Cre: atg7 fl/fl mice	Pyroptosis	Increased	Pu et al. (2017)
ATG16L1	KO	In Vitro Cell line: MEFs	Pyroptosis	No change	Saitoh et al. (2008)
		In Vivo Atg16L1-deficient C57BL/6 mice
ATG12	KD	In Vitro Cell line: Hek293	Apoptosis	Decreased	Rubinstein et al. (2011)
BECN1	OE	In Vitro Cell lines: HCT116, CX-1, HT1080	Ferroptosis	Increased	Song et al. (2018)
	KD	In Vitro Cell lines: HCT116, CX-1	Ferroptosis	Decreased	Song et al. (2018)
SQSTM1	KD	In Vitro Cell line: MEFs	Ferroptosis	Decreased	Yang et al. (2019)

KO, knock out; KD, Knock Down and OE, over expression.