Table 1.
Clinical findings in patients with post-acute COVID-19 syndrome undergoing bilateral orthotopic lung transplantation.
| Age/Sex | Race | BMI | Comorbidities | Vaccination status on admission to CSMC | Medical treatment received before transplant | Duration of ECMO exposure prior to transplant | Time interval between initial diagnosis and transplant | Covid related complications prior to transplant | Clinical follow-up (days after transplant) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Case 1 | 35/F | Caucasian | 22.96 | Pregnancy | Unvaccinated | Convalescent plasma, Remdesivir | 119 | 129 | Stroke, thrombosis, compartment syndrome | 459 |
| Case 2 | 40/M | Hispanic | 26.59 | Ramsay-Hunt syndrome, hypertension | Unvaccinated | Steroid, Remdesivir | 82 | 100 | Bacteremia | 495 |
| Case 3 | 34/F | Hispanic | 28.11 | None | Unvaccinated | Steroid | 87 | 111 | Infection | 382 |
| Case 4 | 51/M | Hispanic | 28.5 | Chronic deep vein thrombosis | Unvaccinated | Steroid Remdesivir, Tociliuzumab | 145 | 199 | Brain hemorrhage | Dead (305) |
| Case 5 | 52/M | African American | 24.12 | Drug/alcohol use | Unvaccinated | Steroid, Remdesivir | 104 | 63 | Pneumothorax, pneumomediastinum, pleural effusion | 381 |
| Case 6 | 55/M | Hispanic | 22.36 | Hypertension | Unknown | Steroid, Remdesivir, Tociliuzumab | 122 | 130 | Stroke, candida sepsis, RV mass, endocarditis | Dead (13) |
| Case 7 | 37/M | Hispanic | 26.73 | Obesity, fatty liver | Unvaccinated | Steroid, Remdesivir, Tociliuzumab | 0 | 71 | None | 360 |
| Case 8 | 38/F | White | 32.7 | Pregnancy | Unvaccinated | Steroid, Remdesivir, Tocilizumab | 78 | 92 | Aspergillus empyema, cardiac tamponade, cardiogenic shock, acute kidney injury | Dead (19) |
| Case 9 | 33/M | Caucasian | 25.24 | None | Unvaccinated | Steroid, Remdesivir | 94 | 106 | None | 244 |
| Case 10 | 46/M | Non-Hispanic | 24.42 | Diabetes | Unvaccinated | Steroid, Remdesivir, Baricitinib | 57 | 121 | Ventilator-associated pneumonia | 246 |
| Case 11 | 61/M | Non-Hispanic | 23.97 | Hyperlipidemia | Unvaccinated | Steroid | 0 | 197 | Steroid-induced hyperglycemia and myopathy, DVT | 217 |
| Case 12 | 33/F | White | 29.68 | Hypothyroidism, depression, obesity | Vaccinated | Steroid, Remdesivir, Baricitinib | 85 | 93 | Pneumothorax, pneumomediastinum, ischemic stroke, hyponatremia, bacteremia with Stenotrophomonas | 205 |
| Case 13 | 66/F | Hispanic | 19.79 | Hypertension, diabetes, ovarian cancer | Unvaccinated | Steroid, Remdesivir | 0 | 409 | Thrombocytopenia, bleeding | 211 |
| Case 14 | 66/M | Hispanic | 21.35 | Hypertension, hyperlipidemia, COPD, former smoker | Unvaccinated | Steroid | 0 | 711 | Pneumothorax, bronchopleural fistula | 244 |
| Case 15 | 38/M | Hispanic | 22.1 | None | Unvaccinated | Not provided | 139 | 150 | Pneumothorax | 198 |
| Case 16 | 24/F | Hispanic | 27.02 | Obesity | Unvaccinated | Steroid | 157 | 169 | Hemothorax, pneumonia | 189 |
| Case 17 | 35/M | Hispanic | 22.77 | None | Vaccinated | Steroid, Remdesivir, Baricitinib | 76 | 79 | None | 153 |
| Case 18 | 57/F | Hispanic | 22.44 | Diabetes, hyperlipidemia, asthma | Vaccinated | Steroid, Remdesivir, Tocilizumab | 57 | 144 | DVT, pulmonary emboli, thrombocytopenia, pneumonia | 125 |
| Case 19 | 52/M | Hispanic | 24.91 | Atrial septal defect | Vaccinated | Steroid, Remdesivir, Tocilizumab | 52 | 401 | Cerebrovascular accident | 90 |
| Case 20 | 25/F | Hispanic | 35.6 | Obesity | Vaccinated | Steroid, Tocilizumab | 25 | 232 | Tension pneumothorax, PEA arrest | 12 |
Abbreviations: BMI: Body mass index, CSMC: Cedars-Sinai Medical Center, ECMO: Extracorporeal membrane oxygenation, RV: Right ventricle, DVT: Deep vein thrombosis, COPD: Chronic obstructive pulmonary disease, PEA: Pulseless electrical activity.