Table 3.
Literature review: Histopathologic findings in explants and surgical biopsy specimens from post-acute COVID-19.
| Pathologic findings in explants |
||||||
|---|---|---|---|---|---|---|
| Fibrosis | Peribronchiolar metaplasia/bronchiolization of alveoli | Delicate alveolar septal calcification | Multinucleated giant cells | Microscopic honeycombing | Cyst formation with giant cell reaction | |
| Luo 2020 (N#1) | Interstitial (#1) | Present (#1) | None | Present (viral inclusion bodies) (#1) | None | None |
| Chen 2020 (N#1) | Interstitial (#1) | None | None | Present (#1) | None | None |
| Bharat 2020 (N#3) | Interstitial (#3) | Present (#3) | None | Present (#1) | Present (#1) | Present (#1) |
| Aesif 2021 (N#1) | Vaguely resemble NSIP (#1) | Present (#1) | None | None | Present (#1) | None |
| Flaifel 2022 (N#3) | Proliferative & fibrotic DAD (#3) | Present (#3) | Present (#1) | Present (#1) | None | None |
| Roden 2022 (N#2) | NSIP (#NS) | Present (#NS) | None | Present (#NS) | Present (#NS) | Present (#NS) |
| Rohr 2022 (N#1) | Organizing DAD with prominent fibrosis (#1) | Present (#1) | None | Present (histoplasma granuloma) (#1) |
None | None |
| Pathologic findings in surgical lung biopsies | ||||||
| Konopka 2021 (N#18) | UIP (#9) | Present (#1) | None | None | Present (#2) | None |
| Aesif 2021 (N#2) | NSIP (#1) | None | None | None | Present (#1) | None |
| Baldi 2022 (N#6) | Peri bronchial (#5) organizing pneumonia (#1) | None | Present (#1) | None | None | None |
| Gagiannis 2021 (N#3) | Organizing pneumonia (#1) | None | None | Present (#1) | None | None |
| Roden 2022 (N#30) | NSIP (#NS) | Present (#NS) | None | Present (#NS) | Present (#NS) | None |
1 Abbreviations: NSIP: Nonspecific interstitial pneumonia, DAD: Diffuse alveolar damage, NS: Not specified, UIP: Usual interstitial pneumonia.