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. 2023 Jun 24. Online ahead of print. doi: 10.1016/j.humpath.2023.06.008

Table 3.

Literature review: Histopathologic findings in explants and surgical biopsy specimens from post-acute COVID-19.


Pathologic findings in explants
Fibrosis Peribronchiolar metaplasia/bronchiolization of alveoli Delicate alveolar septal calcification Multinucleated giant cells Microscopic honeycombing Cyst formation with giant cell reaction
Luo 2020 (N#1) Interstitial (#1) Present (#1) None Present (viral inclusion bodies) (#1) None None
Chen 2020 (N#1) Interstitial (#1) None None Present (#1) None None
Bharat 2020 (N#3) Interstitial (#3) Present (#3) None Present (#1) Present (#1) Present (#1)
Aesif 2021 (N#1) Vaguely resemble NSIP (#1) Present (#1) None None Present (#1) None
Flaifel 2022 (N#3) Proliferative & fibrotic DAD (#3) Present (#3) Present (#1) Present (#1) None None
Roden 2022 (N#2) NSIP (#NS) Present (#NS) None Present (#NS) Present (#NS) Present (#NS)
Rohr 2022 (N#1) Organizing DAD with prominent fibrosis (#1) Present (#1) None Present (histoplasma granuloma)
(#1)
None None
Pathologic findings in surgical lung biopsies
Konopka 2021 (N#18) UIP (#9) Present (#1) None None Present (#2) None
Aesif 2021 (N#2) NSIP (#1) None None None Present (#1) None
Baldi 2022 (N#6) Peri bronchial (#5) organizing pneumonia (#1) None Present (#1) None None None
Gagiannis 2021 (N#3) Organizing pneumonia (#1) None None Present (#1) None None
Roden 2022 (N#30) NSIP (#NS) Present (#NS) None Present (#NS) Present (#NS) None

1 Abbreviations: NSIP: Nonspecific interstitial pneumonia, DAD: Diffuse alveolar damage, NS: Not specified, UIP: Usual interstitial pneumonia.