Table 2.
Hazard Ratios for HF According to MAFLD Status and its subgroups
| Case/Participants | Incidence (/1, 000 person years) | HR (95%CI) | |||
|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||
| Total | |||||
| Non-MAFLD | 1945/67,930 | 2.19(2.09,2.28) | reference | reference | reference |
| MAFLD | 1315/30,755 | 3.29(3.12,3.47) | 1.51(1.40,1.62) | 1.52(1.42,1.63) | 1.40(1.30,1.50) |
| Group by the degree of fatty liver | |||||
| Non-MAFLD | 1945/67,930 | 2.19(2.09,2.28) | reference | reference | reference |
| Mild MAFLD | 809/20,035 | 3.10(2.90,3.32) | 1.41(1.30,1.53) | 1.43(1.31,1.55) | 1.33(1.23,1.45) |
| Moderate MAFLD | 412/8775 | 3.62(3.29,3.99) | 1.66(1.50,1.85) | 1.68(1.50,1.86) | 1.51(1.35,1.68) |
| Severe MAFLD | 94/1945 | 3.77(3.08,4.61) | 1.82(1.50,2.24) | 1.85(1.50,2.27) | 1.57(1.28,1.94) |
| Group by type of metabolic disorder | |||||
| Non-MAFLD | 1945/67,930 | 2.19(2.09,2.28) | reference | reference | reference |
| MAFLD1* | 895/24,590 | 2.77(2.59,2.96) | 1.31(1.21,1.42) | 1.33(1.22,1.43) | 1.27(1.17,1.38) |
| MAFLD2* | 37/1107 | 2.64(1.91,3.64) | 1.09(0.79,1.51) | 1.10(0.79,1.52) | 1.12(0.81,1.55) |
| MAFLD3* | 383/5058 | 6.14(5.56,6.79) | 2.42(2.17,2.70) | 2.43(2.18,2.71) | 1.95(1.73,2.20) |
*MAFLD1: BMI ≥ 23 kg/m2 without diabetes
MAFLD2: BMI < 23 kg/m2 with at least two metabolic abnormalities but not diabetes
MAFLD3: type 2 diabetes mellitus
Model 1: adjusted for age, gender;
Model 2: adjusted for all the variables in model 1 and Smoking, Drinking, Education level, Salt status and Physical activity;
Model 3: adjusted for all the variables in model 2 and Antihypertensive treatment, Antidiabetic treatment and Lipid-lowering treatment