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Interaction and functions of immune cells in tumor microenvironment. Cancer cells, Tregs, NK, TAM, MDSC and CD4 T cells are important immune cells that regulate CD8 T-cell exhaustion. IL-2, IL-6, IL-10, IL12, TGF-β, TNF-α and IFN-γ are all important exogenous cytokines involved in exhausted process of T cells. TAM tumor-associated macrophage, Treg regulatory cells, NK natural killer cell, MDSC myeloid-derived suppressor cells
