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. Author manuscript; available in PMC: 2023 Jun 24.
Published in final edited form as: Nat Genet. 2022 Jul 28;54(8):1178–1191. doi: 10.1038/s41588-022-01134-8

Extended Data Fig. 2 |. Treatment associated with distinct cell type proportions across compartments.

Extended Data Fig. 2 |

Proportions (y axis) of cell types (x axis) in untreated (n = 18), CRT (n = 14), or CRTL (n = 5) tumors out of all non-malignant cells (top left) or in specific non-malignant cell compartments in the tumor. The boxes indicate upper and lower quartiles, with the horizontal lines marking the means. The lines extending vertically from the boxes (whiskers) indicate the maximum and minimum values excluding outliers. Data points are plotted as circles. * Bonferroni adjusted p < 0.05, ** p < 0.01, *** p < 0.001, two-sided Mann-Whitney U test with Bonferroni correction. Exact p-values for significant comparisons were non-malignant myeloid CRT-CRTL = 0.016344, epithelial (non-malignant) ductal CRT-CRTL = 0.031683, lymphoid Treg untreated-CRT = 0.033156, immune CD8+ T CRT-CRTL = 0.03507, immune Treg untreated-CRT = 0.022686.