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. 2023 Jun 24;14:3766. doi: 10.1038/s41467-023-39506-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Myofibers of uninjured and 21 days post CTX (cardiotoxin) injury from Dhh^−/− and control (ctrl) mice are color-coded based on cross sectional area (CSA; µm²). Scale bar: 250 µm. Bottom Right: Average CSA (µm²) of uninjured (n = 16 TAs) and injured (n = 9 TAs) Dhh^−/− compared to uninjured (n = 17 TAs) and injured (n = 14 TAs) control mice. Fiber number distribution based on CSA of Dhh^−/− (n = 9 TAs) and ctrl mice (n = 14 TAs) 21 dpi post CTX. *p = 0.03, ***p = 0.001 and ****p ≤ 0.0001. Source data are provided as a Source Data file. b Experimental outline. c Immunofluorescence and quantifications of MYOG⁺ myoblasts (green) in Dhh^−/− (n = 11 TAs) and ctrl mice (n = 8 TAs) at 3 dpi (days post injury) post CTX. Scale bar: 25 µm. MYH⁺ myofibers (green) in Dhh^−/− (n = 6 TAs) and ctrl mice (n = 6 TAs) at 5 dpi post CTX. Scale bar: 250 µm d Model: DHH is required for successful myofiber regeneration. Nuclei were visualized with DAPI (magenta). All data are represented as mean ± SEM. An unpaired two-tailed t test or a one-way ANOVA followed by a Dunnet’s multiple comparison was used.