Table 1 |.
New IBD-associated genetic loci in EAS
| Index varianta | rsID | EAb | EAFc | Subtype | ORd | P d | Genee |
|---|---|---|---|---|---|---|---|
| chr1:24977085:A:G | rs10903122 | G | 0.68 | CD | 0.86 | 2.84E-11 | RUNX3 |
| chr1:28131939:C:T | rs140466198 | T | 0.10 | CD | 1.30 | 1.05E-08 | PTAFR |
| chr3:112334718:G:A | rs1317244 | A | 0.36 | CD | 1.17 | 2.65E-08 | CD200 |
| chr6:22062256:C:A | rs4712651 | A | 0.65 | UC | 0.83 | 2.53E-11 | CASC15 |
| chr7:950350:G:A | rs77992257 | A | 0.20 | IBD | 0.83 | 1.04E-13 | ADAP1 |
| chr7:37417420:C:G | rs28581678 | G | 0.20 | CD | 1.22 | 3.02E-10 | ELMO1 |
| chr7:74711703:C:T | rs117026326 | T | 0.08 | CD | 1.37 | 8.91E-11 | GTF2I |
| chr8:141164479:C:T | rs438041 | T | 0.53 | CD | 1.17 | 4.10E-08 | DENND3 |
| chr11:118273990:A:G | rs141340254 | G | 0.03 | CD | 0.62 | 4.66E-08 | MPZL2 |
| chr12:96134457:C:G | rs11108429 | G | 0.60 | CD | 1.19 | 7.93E-10 | ELK3 |
| chr12:110259525:G:A | rs117121174 | A | 0.08 | CD | 0.74 | 1.35E-10 | ATP2A2 |
| chr12:116408331:C:T | rs113281820 | T | 0.27 | CD | 1.19 | 1.03E-08 | MIR4472-2 |
| chr16:27384341:C:CT | rs201121732 | CT | 0.02 | UC | 1.63 | 1.75E-08 | IL21R |
| chr17:47280984:G:C | rs11079770 | C | 0.44 | CD | 0.86 | 2.21E-08 | ITGB3 |
| chr18:44806588:T:C | rs16978179 | C | 0.15 | CD | 1.25 | 8.72E-09 | SETBP1 |
| chr19:54219677:C:T | rs255773 | T | 0.51 | CD | 1.24 | 5.28E-09 | LILRB3 |
a
Index variant chosen as the most significant variant in the locus and annotated as CHR:POS:A1:A2. CHR, chromosome; POS, genomic position in genome build 38; A1, reference allele; A2, effect allele.
b
EA, effect allele.
c
EAF, effect allele frequency.
d
OR and P-value are from the inverse-variance-weighted fixed-effect meta-analysis (two-tailed) including all EAS samples.
e
Nearest gene to the index variant.