Fig. 3.

Mechanism of action of A TCEs and B–E structure of DLL3-targeting TCEs in development. Panel A depicts a generic structure for T-cell engagers, although it should be noted that Fc regions are not a feature of all DLL3-targeting T-cell engagers. The structures of the newer DLL3-targeting T-cell engagers RO7616789 and PT217 have not yet been published. CD cluster of differentiation; DLL3 delta-like ligand 3, Fab fragment antigen-binding, Fc fragment crystallizable, scFv single-chain variable fragment, TAA tumor-associated antigen, TCE T-cell engager, TCR T-cell receptor