. Author manuscript; available in PMC: 2023 Jun 25.

Published in final edited form as: AAPS PharmSciTech. 2019 Jan 9;20(2):65. doi: 10.1208/s12249-018-1287-6

Table IV.

Correlation R² and p Values Calculated for Nanoemulsion Day 2 Diameter, 90-day Diameter Increase, and Drug Loading as a Function of Each Parameter Studied in the Mixture Process Variable Design of Experiments. Statistically Significant Correlations (p Value < 0.05) Are Italicized

		Parameter
Response	Statistics parameter	Miglyol	Transcutol	PCE	Microfluidization pulses	Sonication time
Day 2 diameter (nm)	R ²	0.0275	0.2948	0.0018	0.6360	0.0116
Day 2 diameter (nm)	p value	0.5395	0.0298	0.8751	0.0002	0.6914
90-day diameter Increase (%)	R ²	0.1462	0.4975	0.4357	0.0376	0.0212
90-day diameter Increase (%)	p value	0.1438	0.0023	0.0054	0.4714	0.5904
Drug loading (%)	R ²	0.0048	0.3547	0.0258	0.0273	0.2668
Drug loading (%)	p value	0.7984	0.0149	0.5524	0.5406	0.0405