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(A) Comparison of cumulative urine output in patients with acute decompensated heart failure in ADVOR, CLOROTIC, and EMPAG-HF. Cumulative urine output on Day 3 (48 h post-randomization) in each group is calculated based on published data.10,11,20 Per cent change describes group differences compared with placebo in each individual study. (B) Daily urine output under treatment (difference to placebo indexed per day). HCTZ, hydrochlorothiazide.
