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. Author manuscript; available in PMC: 2023 Jun 25.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2022 Sep 13;63:273–293. doi: 10.1146/annurev-pharmtox-051921-084047

Figure 4.

Figure 4.

SPMs act on nociceptive sensory neurons to regulate ion channel function, synaptic transmission, and axonal growth. (a) Location of nociceptor cell body in DRG, peripheral axons terminals in skin and muscle, and central axonal terminals in the spinal cord. (b) SPM receptor signaling in nociceptor cell body and peripheral terminal, leading to reduced activity of TRPV1 and TRPA1 and increased axonal growth. (c) SPM receptor signaling in nociceptor central terminal, leading to reductions in TRPV1 and TRPA1 activity, glutamate release, excitatory synaptic transmission, and spinal cord pain transmission. Abbreviations: EPSC, excitatory postsynaptic current, ERK, extracellular signal-regulated kinase, Glu, glutamate.