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. 2023 Jun 5;5(6):945–954. doi: 10.1038/s42255-023-00811-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Two independent donor sets of human islets were stimulated with 30 nM tirzepatide (TZP) in the presence of 1μM concentrations of exendin(9-39) (Ex9), hGIP(3-30) (GIPR Ant) or the combination. The integrated area under the curve (iAUC) was calculated for both glucose and tirzepatide stimulated insulin secretion using the value of the first time point as the baseline. All values are mean + /- SEM, n = 3/group. A one-way ANOVA with Tukey’s posthoc test was used.

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