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. 2023 Jun 19;5(6):1014–1028. doi: 10.1038/s42255-023-00813-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a, Schematic of the RNA-seq profiling study. b, Scatter-plot of the first two principal components of the RNA-seq samples. Principal component analysis was performed on the expression of the top 1000 most variable genes across all samples. c, Oil Red O staining of progenitor cells after 10-day adipogenic induction. Scale bars, 50 µm. d, Alizarin Red S staining of progenitor cells after 10-day osteogenic induction. e, Volcano plots of differential gene expression analysis between cells induced toward the annotated lineage compared to cells induced to other two lineages. Differentially expressed genes were defined as those with log2 fold change > 1 and adjusted P value < 0.001. f, Gene expression of the most distinctive lineage marker genes, selected based on magnitude and significance in the differential expression analysis as well as specificity. ADIPOQ: adiponectin, COMP: cartilage oligomeric matrix protein, FRZB: frizzled related protein.