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. 2023 Jun 19;5(6):996–1013. doi: 10.1038/s42255-023-00820-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, BEAM analysis identified six kinetic clusters of branch-dependent genes. b, Violin plots of adipogenic marker genes from cluster 2, showing gene expression in branches across depots. c, SWAT cell marker genes from cluster 3, showing gene expression in branches across depots. d, Expression dynamics are displayed as a function of pseudotime (stretched, ranging from 0 to 100) of marker genes for the U branch (ADIPOQ, UCP2) and the L branch (DCN, APOD). Solid lines show smoothed expression curves for each branch. e, FISH staining of human brown adipocytes collected at T5 (halfway through full maturation) using RNAscope probes for branch marker genes. Scale bar, 75 µm. f, GO term enrichment analysis visualized using REViGO and the GOplot R package.