Fig. 7. Label transfer to human adipose tissue and genome-wide association study traits.

a, Uniform manifold approximation and projection dimensionality reduction scatterplots of cells from Palani et al., scRNA-seq (this work) mapped with labels transferred from reference datasets, as annotated in the figure, using Scanorama. Confidence scores are the probability of label assignment by k-nearest neighbours (kNN) classifier. b, Dot plot displaying the expression of top markers for SWAT cells in the ASPC subpopulations as defined⁹. Bar plot on top indicates the number of cells associated with each cell-type annotation. c, CELLECT tool method. d, CELLECT analysis of progenitor, U (adipogenic) and L (SWAT) branch cells, binned by pseudotime deciles. Adipogenic cells with the highest pseudotime values showed significant association with WHR (adjusted to BMI) and low-density lipoprotein. Other traits did not reveal any association.