Druglikeness/ADME/T profile of the positive control acarbose and the most potent compounds 9g, 9a, and 9f.
| Druglikeness/ADME/Ta | Compound | |||
|---|---|---|---|---|
| Acarbose | 9g | 9a | 9f | |
| Rule of five | Violated | Suitable | Suitable | Suitable |
| Caco2 | 9.44448 | 20.3158 | 30.3887 | 36.3747 |
| HIA | 0.000000 | 95.069938 | 96.491176 | 96.334273 |
| BBB | 0.0271005 | 0.0649678 | 0.173469 | 0.289735 |
| Skin permeability | −5.17615 | −3.5438 | −2.73118 | −2.84451 |
| Carcino mouse | Positive | Negative | Negative | Negative |
| Carcino rat | Negative | Negative | Negative | Negative |
| hERG inhibition | Ambiguous | Ambiguous | Ambiguous | Ambiguous |
a
The recommended ranges for Caco2: <25 poor, >500 great, HIA: >80% is high <25% is poor, BBB = −3.0 to 1.2, and skin permeability = −8.0 to −1.0.