Table 1.
Summary of study characteristics, interventions for HBOT and control groups, follow up and reported rates of complete VLU healing.
| Study Title | Study Type | Intervention | Control | Treatment Course | Follow up | No. healed/Sample | |
|---|---|---|---|---|---|---|---|
| HBOT | Control | ||||||
| Hammarlund 1994 | RCT | HBOT at 2.5 ATA for 90 minutes | Hyperbaric air at 2.5 ATA for 90 minutes | 5 sessions/week over 6 weeks | 6 weeks | 0/8 | 0/8 |
| Batora 2005 | Comparative, allocation unspecified | HBOT at 1.8-2 (reported as .18-.2 MPa) for 72 minutes plus unspecified ‘conventional therapy’ | Unspecified ‘conventional therapy’ | ‘Average 26 treatments’ over 6 weeks | 6 weeks | 0/13 | 0/12 |
| Ahmad 2008 | 3-arm RCT | HBOT for 90 minutes daily | Wound cleansing twice daily | 2 sessions/day for 5 weeks | 5 weeks | 0/10 | 0/10 |
| Thistlethwaite 2018 | RCT | HBOT at 2.4 ATA for 80 minutes, plus compression and decompression phases Compression therapy and dressings | Hyperbaric air at 1.05-1.2 ATA for 80 minutes. Compression therapy | 30 sessions | 12 weeks | 6/14 | 6/15 |
| Longobardi 2020 | 3-arm RCT | HBOT at 2.4 ATA for 66 minutes plus compression and decompression phases. Compression therapy | Compression therapy | One HBOT cohort received 2 sessions/day for 3 weeks, the other 1/day for 6 weeks | 3 and 6 weeks | 5/25 | 1/26 |
| ElSharnoby 2022 | Parallel prospective cohort study | HBOT at 2.5 ATA for 1 hour plus compression and decompression phases. Treatment of venous reflux. Compression therapy and dressings. Debridement where necessary | Treatment of venous reflux. Compression therapy and dressings. Debridement where necessary | 5 sessions/week, 20-40 sessions | 12 weeks | 5/12 | 3/13 |
ATA = absolute Atmospheric pressure, mmHg = millimetres of Mercury.