Table 3.

Reduction in VLU area; effect size meta-analysis.

Study Title	Participants	HBOT		Control
	(n = )	Mean Δ VLU Area	SD	Mean Δ VLU Area	SD	SMD	95%CI
Hammarlund 1994	16	35.17(%)	17	2.7	11	2.18	.94	3.42
Batora 2005	25	60.8(%)	42.7	29.3	6.5	.98	.15	1.8
Ahmad 2008	20	1.68	.27	.77	.23	3.47	2.09	4.86
Longobardi 2020 (6 weeks)	48	67.46	40.05	59.72	33.86	.20	−.34	.76
Pooled	109					1.59	.30	2.89

Δ VLU area = change in venous leg ulcer area SD = Standard deviation 95% CI = 95% confidence interval SMD = Standardized mean difference.