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. 2023 Feb 9;43(7):1060–1076. doi: 10.1177/0271678X231156981

Figure 3.

Figure 3.

Selenium supplementation rescues post-tMCAO spatial learning and memory deficits. (a) Experimental timeline. (b) Y maze test to show spontaneous alternation (left), total path travelled (middle) and total arm entries (right) (n = 10 mice per group). (c) Schematic illustration the APA test. The red line encloses a 60° area where an electric shock is delivered. (d) Representative trace graphic on day 5 of the test for three different groups of mice. (e) The improvement over the 5 days of the APA test, expressed as percentage improvement and (f) the mean number of entries to the shock zone (n = 10–12 mice per group). Data represent mean ± SD. (b, e: one-way ANOVA and Bonferroni post hoc comparisons; f: repeated-measures two-way ANOVA (effect of selenium treatment F(2, 31) = 20.28, P < 0.0001) and Bonferroni post hoc comparisons: **P < 0.01, ***P < 0.001, ****P < 0.0001; $P < 0.05, $$P < 0.01, $$$$P < 0.0001; #P < 0.05).