Figure 3.

MRI measures less tracer in the intracranial space than SPECT at first but converges with SPECT measurements as time progresses. Mean tracer concentration over time in the rat intracranial space under K/D or isoflurane anesthesia as imaged by SPECT or MRI. n = 4–5. The grey shaded area depicts time when the pump is on. The colored shaded areas on the line plots and the error on the bar plots are the standard deviation. KD: ketamine-dexmedetomidine; Iso: isoflurane; AUC: area under the curve; ID: injected dose. Two-sided independent t-test, ** = P < 0.001.