Figure 3.

(a) Infants were classified into four groups: 1) those that were below the cut-off at all three time points, 2) below the cut-off at 0–6 h but above one or both the 24–48 h and 48–72 h epochs, 3) above the 0–6 h cut-off but below at least one of the 24–48 h or 48–72 h cut-offs, and 4) above all three cut-offs. Adjusted odds ratio (aOR) for death or moderate-severe neurodevelopmental impairment (NDI) by 0–6 h, 24–48 h, and 48–72 h temperature cut-offs in all infants (b), in those surviving to discharge (c), and separately in those with moderate (d) and severe (e) encephalopathy. Percentages indicate those with NDI-free survival within each Continued.trajectory group. Using Group 4 as the reference group, Groups 1 and 2 both had significantly reduced odds for death or NDI in all infants as well as those surviving to discharge, with a nonsignificant decrease in odds in Group 3. Regardless of severity of encephalopathy, being below all three cut-offs (Group 1) was associated with 100% NDI-free survival. All models were adjusted for exposure to phenobarbital, inotropes, and morphine, documented seizures, severity of encephalopathy (except D and E), duration of therapeutic hypothermia treatment, and degree of organ dysfunction.