Table 4.

Epoch-specific mattress temperature (MT) cut-offs to predict primary outcome.

	Optimal cut-off	Infants above cut-point (all data)
Time epoch	Temperature (°C)	n = (%)	OR for death or NDI (95% CI)
0–6 h	≥33.0	107 (65.2)	17.0 (4.3–67.4)
6–24 h	≥31.0	104 (77.0)	3.3 (0.9–12.3)
24–48 h	≥31.0	92 (56.4)	3.1 (1.3–7.5)
48–72 h	≥32.0	99 (60.7)	3.3 (1.3–8.4)

Epoch-specific cut-offs of average MT to predict primary outcome were determined within each epoch separately due to the fluctuating nature of average MT over time (Figure 2). Cut-offs were determined using the cutpointr library in R with five-fold cross validation. Adjusted odds ratios (aOR) with 95% CI are provided for the whole dataset after adjusting for severity of encephalopathy at enrollment, length of TH treatment, exposure to phenobarbital, morphine, or inotropes, and degree of organ dysfunction. aORs with the confidence intervals that does not cross 1 are highlighted in bold. NDI: neurodevelopmental impairment.