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. 2023 May 28;26(6):106963. doi: 10.1016/j.isci.2023.106963

Figure 4.

Figure 4

Vaccine protection with BCG and ΔLprG after repeated 1 MID50 H37Rv challenge in C3HeB/FeJ mice

(A) Study design (A).

(B) Two cohorts of C3HeB/FeJ mice (n = 18 mice per cohort, n = 36 mice total) were divided equally into naive, BCG, and ΔLprG groups. Vaccines were administered at week 0 followed by four weekly 1 MID50 H37Rv aerosol challenges between weeks 8–11 and right and left lung lobe harvesting at week 15 for lung lobe bacterial load quantification (B).

Bottom dotted line represents an LOD of 5 CFU. Histograms and dot plots summarizing data are shown in B (C–E). p values for infection rates between groups represent an exact logistic regression model (C and D). p values for bacterial loads between groups represent a mixed effects negative binomial model (E). For (E), bottom dotted line represents an LOD of 5 CFU and bars represent group medians. For all panels, ∗ represents p < 0.05 and ∗∗∗ represents p < 0.001.