Figure 5.

Behavioral control of sound dimensions is plastic and amenable to training

(A) Left: Generalization gradients after initial training (first conditioning) with safe (blue square) and unsafe (red) sounds combined differences in frequency range and sweep direction. (A) Middle: Generalization gradient after subsequent conditioning to the non-dominant dimension, sweep direction (the second conditioning). (A) Right, d’ for the last 50 unsafe visits of the first and the second conditioning for individual mice. Paired t-test was used to check the difference between performances after each conditioning. p values less than 0.01 are given two asterisks. (A) Mice initially selectively generalized along frequency range (left) and were worst at direction discrimination (middle).

(B) Same as (A) for mice initially trained with sweep direction and rate (left), and subsequently trained to discriminate the non-dominant dimension, rate (middle).

(C and D) Left: Generalization gradients after the first conditioning with direction and duration. Mice initially generalized along both direction and duration dimensions. (C and D) Right: Shift in generalization pattern after the second conditioning to discriminate either direction (C) or duration (D). Responses to the safe and unsafe sound are marked as blue and red, respectively. Error bars represent standard error throughout.