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. 2023 May 23;26(6):106960. doi: 10.1016/j.isci.2023.106960

Figure 3.

Figure 3

Gavage of Western diet-fed Apoe−/− mice with live bacteria downregulates expression of genes involved in lipogenic pathways and upregulates expression of genes involved in circadian rhythm

(A–D) Volcano plots showing transcriptome-wide changes in mRNA levels. The significantly upregulated or downregulated genes (FDR < 0.05 and the absolute value of fold change >1) are marked in red and blue, respectively.

(E) Heatmap of genes related to biosynthesis and metabolism of lipids in mice treated with vehicle or live bacteria.

(F) Heatmap of the genes related to the regulation of circadian rhythm in mice treated with vehicle or live bacteria. The red areas represent highly expressed genes and blue areas represent lowly expressed genes. Apoe−/− control, western diet-fed Apoe−/− mice treated with vehicle (n = 6); B, Western diet-fed Apoe−/− mice treated with B. cellulosilyticus (n = 7); F, Western diet-fed Apoe−/− mice treated with F. longum (n = 8); R, Western diet-fed Apoe−/− mice treated with R. intestinalis (n = 7); B,F,R, Western diet-fed Apoe−/− mice treated with the consortium of the three bacteria (n = 5).