Figure 5.
The interventions change the fecal microbiome composition and the changes link to lipids
(A) Visualization of the fecal microbiota composition at baseline and at the endpoint of the intervention in mice receiving each individual bacterium or the consortium of all three bacteria. Microbiota composition is represented by multidimensional scaling (genus level Aitchison distance). Before represents baseline. After represents the end of the study. Intervention effects are symbolized by the colored arrows, with direction and length corresponding to the shift in group centroid coordinates from each intervention group to control group. Fecal composition of all groups was not different at baseline while microbiota composition of intervention group was different from that of control group at the end of study.
(B) Lipid-associated taxa. The β (the linear model coefficients, dot) ±SE for each taxon that was significantly associated with the lipid parameter. An asterisk before the label indicates a taxon that has been reported as having the ability for transforming bile acid and a circle before the label represents a taxon producing acetic acid.
(C) Treatment effect on lipid-associated taxa. The coefficient β±SE represents the treatment effect on lipid associated taxa in b compared to the control group at the end of the study. A comparison of the effects of treatment and control on growth rates of each taxon was performed using a mixed effects linear model by interaction between weeks in the intervention and treatment (coefficient β3±SE) and a random intercept for each mouse.