TABLE 3.
Previous studies evaluating the prognostic significance of viral status in nasopharyngeal carcinoma (NPC)
| Study | No. of Pts (EBV+/ HPV+/viral negative) | Study dates | Median follow-up time (Mo) | Comparison | Conclusion |
|---|---|---|---|---|---|
| Yip et al29 | 80 | 1985–1992 | 136.8 | EBV positive vs EBV negative | EBV positive had increased OS compared to EBV negative |
| Lin et al30 | 24 | 1993–2010 | 48 | EBV positive vs EBV negative | No significant difference in OS |
| Jiang et al31 | 86 | 2000–2014 | 36 | EBV positive vs EBV negative | EBV positive had increased OS, PFS and LRC compared to EBV negative |
| Peng et a32 | 1106 | 2009–2012 | 49.8 | EBV positive vs EBV negative | Among patients with advanced stage (III-IVB) NPC, EBV positive had decreased OS and PFS compared to EBV negative |
| Huang et al24 | 31 | 2003–2004 | 38 | HPV positive vs HPV negative | No significant difference in PFS |
| Atighechi et al25 | 41 | 1995–2007 | 48 | HPV positive vs HPV negative | HPV negative had higher recurrence and mortality rates compared to HPV positive |
| Fakhry et al26 | 125 | 1995–2012 | 42 | HPV positive vs HPV negative | No significant difference in OS |
| Li et al27 | NCDB: 1006 | 2010–2014 | HPV positive vs HPV negative | No significant difference in OS | |
| Verma et al28 | NCDB: 956 | 2004–2013 | 23 | HPV positive vs HPV negative | No significant difference in OS |
| Dogan et al14 | 63 (38/6/19) | 1981–2012 | 38 | EBV vs HPV vs viral negative | Viral negative had worse OS than HPV or EBV positive. No significant difference in OS between HPV and EBV positive |
| Robinson et al15 | 67(47/11/9) | 2000–2012 | 26 | EBV vs HPV vs viral negative | No significant difference in OS between groups |
| Wilson et al16 | 13 (5/4/4) | 2002–2013 | 30.1 | EBV vs HPV vs viral negative | Viral association (EBV or HPV) was a predictor of increased OS. No significant difference in OS between EBV and HPV |
| Stenmark et al17 | 62 (26/18/17) | 1985–2011 | 84 | EBV vs HPV vs viral negative | Viral negative had worst OS, PFS and LRC. HPV positive had worse OS, PFS, and LRC than EBV positive |
| Kano et al18 | 59 (49/2a/8) | 1996–2015 | 58 | EBV vs HPV vs viral negative | No significant difference in OS between groups |
Abbreviations: CI, confidence interval; EBV, Epstein-Barr virus; HR, hazard ratio; HPV, human papillomavirus; OS, overall survival.
a
Patients were EBV and HPV positive.