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. 2023 Jun 7;66(12):7894–7908. doi: 10.1021/acs.jmedchem.3c00269

Table 2. Selectivity Indices Calculated for Each Tumor Cell Linea.

compound HeLa MDA-MB-231 MCF-7 HCT-116 A2780 A2780cisR
1 0.46 0.71 0.23 2.13 0.89 2.80
2 0.74 1.48 0.37 1.35 5.49 5.35
3 1.06 1.86 1.63 3.35 5.58 5.15
4 1.03 1.10 0.97 1.78 6.40 4.00
cisplatin 0.50 0.33 0.53 0.88 2.07 0.37
DCF 1.78 2.38 1.72 2.11 1.86 3.22
enDCF 1.93 1.81 1.57 2.15 ND ND
a

SIs were calculated as IC50 (MRC-5)/IC50 (individual cancer cell line).