Table 3. Amount of Platinum Taken up by HeLa Cells Within 24 h (at 0.1 μM Complex Concentration), or 6 h (1 and 10 μM Complex Concentration), and Log P Values of the Investigated Complexes.
| cellular
uptake (ng Pt/106 cells) |
||||
|---|---|---|---|---|
| complex | 0.1 μM/24 h | 1 μM/6 h | 10 μM/6 h | log Pa |
| 1 | 4.4 ± 0.5 | 13 ± 3 | 72 ± 2 | –1.7 ± 0.2 |
| 2 | 2.2 ± 0.2 | 6.2 ± 0.3 | 47 ± 2 | –2.1 ± 0.2 |
| 3 | 3.6 ± 0.2 | 9.6 ± 0.8 | 61 ± 8 | –1.7 ± 0.1 |
| 4 | 3.9 ± 0.3 | 11 ± 2 | 82 ± 7 | –1.4 ± 0.1 |
| cisplatin | 0.3 ± 0.1 | 2.3 ± 0.3 | 10 ± 3 | –2.3 ± 0.3 |
a
Log P (octanol/water) values for the tested platinum compounds determined by the “shake-flask” method.