Table 2.

Comparison of different rodent models of NAFLD.

	Obesity	Insulin resistance	Steatosis	Fibrosis	NASH
Dietary models
MCD	No	Hepatic IR only	Yes	Yes	Yes
CDAA	No	No	Yes	Yes	Yes
HFD	Yes	Yes	Yes	No	No
HFHS (inc. fructose/glucose/sucrose)	Yes	Yes	Yes	Some	Some
Chemical/pharmacological
STZ + HFD	Yes	Yes	Yes	Yes	Yes
CCL4	No	No	Yes	Yes	Yes
Paracetamol	No	No	Yes	Yes	Yes
Genetic models
ob/ob mice	Yes	Yes	Yes	No	No
db/db mice	Yes	Yes	Yes	No	No
PTEN knockout mice	No	No	Yes	Yes	Yes
SREBP-1c transgenic mice	Weight loss	Yes	Yes	Yes	Yes
KK-Ay/a mice	Yes	Yes	Yes	No	No
PPAR-α knockout mice	No	No	Yes	No	No
AOX knockout mice	No	No	Yes	No	Yes (transient)
CD36 knockout mice	No	Hepatic IR only	Yes	No	Yes
ApoE knockout mice	No	No	Yes	No	No