Table 14.
Hyperimmune IgYs—immunogens preparation and application of products.
| IgY Specificity | Vaccine Preparation | Application | Reference |
|---|---|---|---|
| Digestive tract | |||
| S. typhimurium, E. coli (F18ab) | Inactivated bacteria (formaldehyde), immunized separately; adjuvant not specified | Pharmaceutical composition, powder that can be formulated for oral use | Butz et al. (359) |
| Rotavirus, Escherichia coli (ETEC), E. coli (Shiga toxin-positive) and Salmonella | Inactivated antigens used separately | IgY combined with colostrum as anti-diarrhea supplement | Grabowsky et al., Gaensbauer et al. (362, 363) |
|
E. coli. (ETEC) Salmonella enteritidis, Salmonella typhimurium, H. pylori |
Mixed (all four, or first three) or separately used, inactivated bacteria (formaldehyde); adjuvant not specified | Ice-cream, yogurt, mayonnaise (whole eggs used) | Lee et al. (366) |
| E. coli. (ETEC), H. pylori | Mixed inactivated bacteria (formaldehyde); adjuvant not specified | Ice-cream, yogurt | Baek et al. (365) |
| E. coli (ETEC), H. pylori | Mixed inactivated bacterial antigens (formaldehyde); adjuvant not specified | Kimchi, soy sauce, soybean paste, fruit juice | Choi et al., Lee et al., Baek et al. (367–370) |
| E. sakazakii, Salmonella | Mixed antigens | Immune milk powder for children | Bao et al. (371) |
| A. hydrophila, B. cereus, C. jejuni, C. perfringens, E. coli (0157:R7), Lactobacillius, L. monocytogens, S. cerevisae, S. enteritidis, S. typhimurium, S. aureus, S. epidermidis | Separately used thermally or chemically inactivated bacteria cells; adjuvant not specified | Processed meat products, e.g., grill sausages as a sterilization or bacteria growth inhibition substance | Song et al. (372) |
| Mouth | |||
| S. mutans (serotype C, D, and G), A. actinomycetemcomitans, F. nucleatum, P. gingivalis, A. viscosus, C. ochracea, T. denticola, B. forsythus | Mixed bacterial antigen | Anti-caries and anti-periodontal disease and anti-halitosis toothpaste | Paau and Yang (373) |
|
S. mutans and S. sobrinus;
F. nucleatum and P. gingivalis, |
Whole cells or whole cells and cell fragments. The immunization with all antigens or with mixed two bacteria at a time (anti-caries or anti-periodontal) | Anti-caries, anti-periodontal disease or anti- bad breath toothpaste | Chen et al. (374, 375) |
| P. gingivalis, F. nucleatum, S. moorei | Mixed bacterial antigen | Mouthwash for preventing and treatment of bad breath | Zhao et al. (376) |
| P. gingivalis, F. nucleatum | Mixed or separately used whole cells with or without bacteria fragments fraction | Anti-bad breath mouthwash | Chen et al. (377) |
| S. mutans, P. gingivalis, H. pylori | Separately used inactivated whole cells | Oral spay, lozenge, chewing gum | Pang et al. (378) |
| P. gingivalis, A. actinomycete | Mixed disintegrated bacterial suspension | Oral spay | Zou and Jia (379) |
| S. aureus, E. coli, S. mutans, P. gingivalis, hemolytic Streptococcus, C. albicans | Mixed bacterial antigen; adjuvant not specified | Medical chewing gum | Meng et al. (380) |
|
A. actinomycetemcomitans (polysaccharide antigen), P. gingivalis (polysaccharide antigen), F. nucleatum, C. rectus, B. forsythus
T. denticola, S. mutans |
Separately immunized, for polisacharides the BSA conjugates were prepared, for the rest of bacteria, formaldehyde inactivated whole cells were used; adjuvant not specified | Tooth coating composite | Oka (381) |
| S. mutans, P. gingivalis, C. nucleus, A. viscosus, Actinomyces spp. | Mixed bacterial antigens | Anti-caries and anti-periodontal disease milk powder | Sheng et al. (382) |
| Skin | |||
| P. aeruginosa, E. coli, S. aureus, β-hemolytic Streptococcus | Mixed proteins antigen obtained after cells disruption | Cream for burn treatment | Chao & Zhenqiang (383) |
| P. aeruginosa, E. coli, S. aureus | Mixed inactivated bacteria cells | Antibacterial spray for application on burns and wounds | Lin (384) |
| S. aureus, E. coli, A. baumannii, P. aeruginosa, β-hemolytic Streptococcus group A, C. albicans | Mixed inactivated bacteria | Wound treatment cleaning composition, band-aid, and liquid | Yongxiang et al., Meng et al. (385, 386) |
| P. acnes, S. aureus | Mixed bacterial cell fragments soluble fraction from disintegrated cells | Anti-acne spray | Fu (387) |
| P. acnes, S. aureus, P. aeruginosa, E. coli, hemolytic Streptococcus, C. albicans | Mixed inactivated cells | Mask with antibacterial and acne activity | Nong et al. (388) |
| P. acnes, S. aureus, P. aeruginosa, hemolytic Streptococcus, C. albicans | Mixed inactivated cells | Antibacterial and anti-acne toner, mask mud, and gel sleep mask | Meng et al. (389) |
| Respiratory tract | |||
| S. aureus, hemolytic Streptococcus, S. pneumoniae, E. coli, A. baumannii, P. aeruginosa | Mixed inactivated bacterial cells | Inhalation solution for respiratory tract infections | Nong et al. (390) |
| S. aureus, E. coli, β-hemolytic Streptococcus | Mixed or separately used inactivated bacterial antigens | Throat-moistening lozenges | Jiang et al. (391) |
| S. pneumoniae, β-hemolytic Streptococcus group A, H. influenzae, S. aureus, S. graminis, S. albicans, M. catarrhalis | Mixed bacterial antigens | Anti-pharyngitis milk powder for infants | Sheng et al. (382) |
| Gynecological | |||
| Papillomavirus, S. aureus, E. coli, P. aeruginosa, C. albicans, β-hemolytic Streptococcus group A | Mixed inactivated antigens | Vaginal gel or foaming agents | Fu et al. (392, 393) |
| C. albicans, S. aureus, N. gonorrhoeae, G. vaginalis, (papillomavirus *) | Protein extract used as a mixture. | Preparation for gynecological inflammations | Zhang (394) |
| S. aureus, P. aeruginosa, E. coli, S. mutans, C. albicans, β-hemolytic Streptococcus group A | Mixed inactivated antigens | Composition against mouth and gynecological infections | Duan et al. (395) |
*Optional HPV recombinant proteins.
If not specified in the Vaccine Preparation column, then FCA/FIA was used as an adjuvant.