Table 8.

Studies concerning the production and application of IgY antibodies specific to Campylobacter jejuni.

Immunogen	Activity/Properties	Reference
CadF, FlaA, MOMP, FlpA, and CmeC recombinant proteins of C. jejuni	In vitro/in cellulo; immunofluorescence, Western blot, and adhesion inhibition assay; specific against CAP IgY recognize C. jejuni cells and recombinant CAPs; anti-CadF, MOMP, and CmeC IgY reduce adherence of C. jejuni to LMH cells	Al-Adwani et al. (197)
CadF, FlaA, MOMP, FlpA, and CmeC, Peb1A, JlpA recombinant proteins of C. jejuni	Chickens, oral administration; lack of difference between hyperimmunized egg yolk powder treated and non-treated animals	Paul et al. (198)
C. jejuni KC40 whole-cell lysate and hydrophobic protein fraction	Chickens, oral administration; reduced amount of cecal C. jejuni after administration specific IgYs	Hermans et al. (199)
4 strains of C. jejuni for oral inoculation; C. jejuni OMP extracts or formalin-inactivated 4 strains of C. jejuni	In vitro; agglutination, motility and bactericidal assays; similar agglutination and bactericidal potential of IgY obtained according to different protocols	Thibodeau et al. (200)
Oral inoculation with live C. jejuni mixture strains (OI); OMP proteins or formalin- inactivated C. jejuni strains	In vitro/in vivo, chickens; oral administration; lack of significant in vivo activity against C. jejuni cecal colonization	Garba et al. (201)
Bacterin (13 different strains of C. jejuni, formalin-inactivated); composition of recombinant proteins AtpA, Ef-Tu, GroEL, Tig, CheV, and LivJ	Chickens, oral administration; prophylactic activity of obtained IgYs, especially anti-bacterin, reduction in cecal C. jejuni after therapeutic administration of IgYs	Vandeputte et al. (202)
Enterobactin conjugate (Ent-KLH)	Chickens, oral administration; administration of anti-Ent IgY did not confer protection against C. jejuni colonization	Wang et al. (203) Zeng et al. (204)

If not specified in the Activity/Properties column, then FCA/FIA was used as an adjuvant.