Table 9.

Studies concerning the production and application of IgY antibodies specific to C. difficile.

Immunogen	Activity/Properties	Reference
Recombinant FliD protein	In vivo, hamsters; 0.5 mg of IgY per day for 10 days; increased animals survival	Murvey et al. (205)
Inactivated C. difficile spores (paraformaldehyde)	In vivo, murine model; IgY of 100, 200, and 600 µg, pre- and post-inoculation and for 3 following days, IgY of 600 µg + vancomycin of 50 mg/kg, days 3–9 delayed signs of infection	Pizzaro-Guajardo et al. (206)
C. difficile specific	In vivo, human case study; 10 g/day combine therapy with probiotic bacteria; infection clearance; no data specified concerning adjuvant	Borody (207)

If not specified in the Activity/Properties column, then FCA/FIA was used as an adjuvant.