Appendix Table 1.

^*

Modifiable with nurses

Non-modifiable with nurses

Insertion Central Line Insertion Practices (CLIP) understanding and observation Chlorhexidine impregnated transparent occlusive dressing Maintenance bundle training Hand hygiene Daily assessment Review of central line necessity, evidence of infection, inflammation, or pain at the site of insertion of catheter Scrub the hub with 70% alcohol before accessing it

Emergency line insertion Type of line chosen Multiple lumens or connectors- due to more supports Femoral site of insertion and continuation due to patients clinical condition which after discussion with CCU consultants could not be avoided Patients on steroids, injection tocilizumab, other immunosuppressive drugs Patients on anticoagulants bleeding and oozing at site of insertion (chlorhexidine-impregnated dressings) Patients on prone ventilation Patients with multiple comorbidity Duration of hospitalization

*After brain storming, the factors were divided into modifiable and non-modifiable as shown in Appendix Table 1