TABLE 2.
Patient demographics and baseline characteristics1
| Median (range) / N (%) | |
|---|---|
| Number of subjects | 51 |
| Female/Male | 28 (55%) / 23 (45%) |
| Age (years) | 4.9 (0.25–14.9) |
| Weight (kg) | 15.6 (6.2–97.5) |
| Body surface area (m2) | 0.68 (0.31–1.89) |
| Serum creatinine (mg/dL) | 0.3 (0.1–0.5) |
| Creatinine clearance (mL/min/1.73m2)2 | 150 (96–150) |
| White Blood Cell Count (109 cells/L) | 2.9 (0.1–11.7) |
| Combination Pretransplant Conditioning Regimen | |
| Clofarabine 40mg/m2 / melphalan / total body irradiation | 15 (29.4%) |
| Clofarabine 10mg/m2 / fludarabine / busulfan | 18 (35.3%) |
| Clofarabine 30mg/m2 / fludarabine / busulfan | 18 (35.3%) |
1
Laboratory data was collected on the day of pharmacokinetic sampling, prior to drug administration.
2
Creatinine clearance was estimated in children using the Schwartz method and in young adults greater than 17 years of age by the Cockcroft-Gault equation using ideal body weight.