TABLE 3.

Final population PK model parameter estimates and bootstrap results

	Final Model Results		Bootstrap Results
Population PK Parameters	Parameter Estimates	RSE (% mean)1	Mean Values	95% Confidence Interval
Typical value for clo-fara CL (L/h/15kg)	23.4	6.30	23.4	20.7–26.2
Volume of the central compartment (${\text{V}}_{\text{c}}$, L/15kg)	42.3	11.6	42.3	32.5–52.2
Inter-compartmental CL (L//h/kg)2	9.82	9.88	9.82	7.91–11.8
Volume of the peripheral compartment (${\text{V}}_{\text{p}}$,L/15kg)	47.4	6.14	47.3	42.0–53.8
Maturation half-time (${\text{T}}_{\text{half}}$, years)	0.41	42.2	0.43	0.17–0.81
Inter-individual variability on CL (%CV)	25.7	39.0	24.2	10.2–32.7
Inter-individual variability on Vc4 (%CV)	40.3	26.5	40.1	22.7–52.0
Proportional residual unexplained variability (%)	33.2	8.89	32.7
Additive error (ng/mL)	0.36	6.43	0.36

¹Relative standard error (%)

²First order rate constant for drug moving from the central compartment to the intracellular compartment