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Comparison of daily and cumulative exposure of clo-fara in the observed data presented by clofarabine daily regimen.
| Clofarabine Regimen | Number of Subjects | Total Number of Doses | AUC0–24 (mg•hr/L)1 | cumulative AUC (mg•hr/L) |
|---|---|---|---|---|
| All dose regimens | 0.78 (0.22 – 4.0) | 3.3 (0.87 – 20.0) | ||
| 10 mg/m2/dose | 18 | 4 | 0.30 (0.22 – 0.36) | 1.2 (0.87 – 1.44) |
| 30 mg/m2/dose | 18 | 4 | 0.82 (0.37 – 1.39) | 3.3 (1.5 – 5.5) |
| 40 mg/m2/dose | 15 | 5 | 1.04 (0.87 – 4.0) | 5.2 (4.4 – 20.0) |
Presented as median (range)
