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. 2023 Jun 26;21:201. doi: 10.1186/s12951-023-01955-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Mild magnetothermal performance of various forms of MBRs-Fe₃O₄/GOx/MgCO₃@PLGA gels in vitro and in vivo. (A) In vitro infrared thermal images of Fe₃O₄/MgCO₃@GOx-PLGA with different volumes and various mass fractions of Fe₃O₄ nanoparticles. (B) Corresponding quantitative temperature curves of saline and MBRs (incorporated with different mass fractions of Fe₃O₄ nanoparticles). (C) Corresponding quantitative temperature curves of 10% Fe₃O₄-MBRs with various volumes. (D) Quantitative temperature curves of 75 µL 10% Fe₃O₄-MBRs for “on-off” model magnetothermal in vitro bovine liver treatment with corresponding infrared thermal images and digital images of several cycles. (E) Temperature-time curve of 143B tumor-bearing mice after intratumoral injection of MBRs and AMF exposure for five on-off cycles and the corresponding infrared thermal images