Table 2.

Performance of individual and combined biomarkers in detecting recurrent ovarian cancer

	AUC (95% CI)	SN (%)	SP (%)
Healthy controls vs primary OvCa
IL-6 R alpha	0.618 (0.492–0.743)	21.7&	85
GDF-15	0.737 (0.624–0.849)	43.5#	85
IL-6	0.739 (0.626–0.852)	41.3$	85
GDF-15 + IL-6 + IL-6 R alpha	0.844 (0.758–0.930)	65.2	85
Healthy controls vs recurrent OvCa
IL-6 R alpha	0.650 (0.519–0.782)	30.4&	83
IL-6	0.801 (0.685–0.916)	50.0&	83
GDF-15	0.856 (0.771–0.942)	69.6#	83
GDF-15 + IL-6 + IL-6 R alpha	0.904 (0.829–0.979)	84.8	83
Primary vs recurrent OvCa
CA-125	0.700 (0.551–0.848)	37.5#	83
VCAM-1	0.729 (0.580–0.879)	58.3	83
CA-125 + VCAM-1	0.813 (0.687–0.938)	70.8	83

OvCA ovarian cancer, AUC area under curve, CI confidence interval, SN sensitivity, SP specificity. One-sided McNemar test comparing sensitivity against individual markers: ^*p < 0.05; ^#p < 0.01; ^$p < 0.001; ^&p < 0.0001